The past decades have witnessed the rapid advancements of computational intelligence techniques, including big data, machine learning, and knowledge engineering, in both industrial and academic communities. Specifically, with the diffusion of some computing paradigms such as natural language processing, knowledge graph, reasoning decision, it promotes the computer-assisted diagnosis and treatment in Traditional Chinese Medicine (TCM). Through the integration of our research achievements in the field of intelligent information processing on TCM over the last decade, this book introduces the data processing technologies in TCM medical records and TCM medication, the medical records-based knowledge acquisition, the text-based knowledge acquisition, and the applications of TCM knowledge. We would like to provide a guidance for graduate students, university teachers and professional technicians engaged in knowledge engineering and TCM informatization.